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Molecules, Transport and Health

The Heart and Circulation

Pearson Edexcel International A Level Biology


Why animals need a heart and circulation

  • In a large animal diffusion is too slow and the diffusion distance is too great: cells are too far away from the gut and the gas exchange surface.
  • In a small organism the cells will not be far from the blood, and it has a low metabolic rate.
  • A double circulation keeps oxygenated and deoxygenated blood separate.

Blood vessels

LumenTunica intimaTunica mediaTunica externaLumenValve
An artery and a vein cut open, showing the layers of the wall.
VesselStructureFunction
Arteryelastic fibresexpansion of elastic fibres under the high pressure of blood leaving the ventricle; elastic recoil to maintain the high blood pressure
Arterycollagengives the wall tensile strength to withstand pressure and prevent rupturing
Small arterysmooth musclecontrol blood flow; maintain blood pressure
Arterysmooth endotheliumreduces friction
Veinvalves along the lengthto prevent backflow, as blood returns under low pressure and against gravity
Capillarywall only one cell thickshort diffusion distance, where gas exchange takes place
Capillaryporesplasma forced out; molecules can leave
Capillarysmall diameterall cells close to capillaries
  • Lining of endothelial cells in arteries, capillaries and veins.
  • More capillaries: more capillaries are in contact with the cells, which results in faster diffusion.
  • A drawing of an artery in section shows the lumen and three layers: tunica externa, tunica media and tunica intima.

Flow and pressure along the vessels

  • Blood in the aorta is under higher pressure as it has just been pumped out of the left ventricle.
  • Pressure decreases the further the blood gets from the heart: the aorta branches into many arteries, and the friction between blood and vessel slows the blood.
  • Velocity decreases as blood flows through the arterioles, is low as blood flows through the capillaries and increases as blood flows through the venules.
  • Describe the velocity of the blood. Never write blood pressure falls through the capillaries to describe the flow.

Structure of the heart

vena cavaright atriumrightatrioventricularvalveright ventricleaortapulmonary arterypulmonary veinleft atriumsemilunar valveleftatrioventricularvalveleft ventricle
A section through the heart, showing the chambers, the valves and the vessels that enter and leave.
StructureLeftRight
Blood enters frompulmonary veinvena cava
Atriumleft atriumright atrium
Valveatrioventricular valveatrioventricular valve
Ventricleleft ventricleright ventricle
Valvesemilunar valvesemilunar valve
Blood leaves byaortapulmonary artery
  • Oxygenated blood returns to the heart in the pulmonary vein; the left ventricle pumps it to the body. Never write oxygenated blood returns in the vena cava.
  • Ventricle walls thicker than atrium walls.
  • The right ventricle has thinner walls as blood is only pumped to lungs: lower pressure on the right side to prevent damage to alveoli.
  • The mammalian heart has a septum and two ventricles, giving a double circulation; the left hand side and right hand side beat simultaneously.
  • The coronary artery branches from the aorta, the closest vessel carrying oxygenated blood, and carries oxygenated blood to the heart muscle for aerobic respiration.
  • The atrioventricular valve prevents backflow into atrium; the cords prevent valve from going inside out, and the papillary muscle pulls on cords.

The cardiac cycle

TimePressureAtrioventricularvalve closesSemilunarvalve opensSemilunarvalve closesAtrioventricularvalve opensAortaAtriumVentricle
Pressure in the left atrium, left ventricle and aorta through one cardiac cycle, with the point where each valve opens or closes.
  1. Atrial systole: the atria contract; increase in volume of the ventricles as the atria squeeze blood into them.
  2. Ventricular systole: the ventricles contract; decrease in volume as blood is pumped out into the aorta and pulmonary artery.
  3. Cardiac diastole: atria and ventricles relaxed; the atrioventricular valves are open, the semilunar valves are closed, and the ventricles start to fill.
  • The atrium has higher pressure than the ventricle, so the atrioventricular valve opens.
  • The ventricle has higher pressure than the atrium, so the atrioventricular valve closes.
  • The ventricle has higher pressure than the aorta, so the semilunar valve opens.
  • The aorta has higher pressure than the ventricle as the heart relaxes, so the semilunar valve closes.
  • Write cardiac diastole for the stage when the whole heart is relaxed. Never name the stage ventricular diastole.
  • The duration of diastole and systole decrease with increase in heart rate.
When the atrioventricular valves close

Write the atrioventricular valves have to close before the ventricles contract, to prevent backflow of blood into the atria. Never write atrioventricular valves close during ventricular systole: the valves must already be shut when the ventricles contract, or blood is forced back into the atria.

HR = 
60T
QuantitySymbolUnit
Heart rateHRbeats min−1
Length of one cardiac cycleTs

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